DS-Qi2 microscopy digital camera equipped with a Nikon digital SLR camera FX-format CMOS sensor optimized for microscopy. The newly developed 16.25-megapixel monochrome CMOS sensor for the monochrome digital camera for microscopes offers 36.0 x 23.9 mm image size. The S/N ratio is five times better than that of conventional models, with quantum efficiency*1 up to 77% and 2.2-electron readout noise. In addition, Peltier cooling (electronic cooling) reduces dark-current noise*2 and produces clear images with reduced noise even with dark fluorescent specimens.